THE MAIN SYMPTOMS OF NOCTURNAL PAROXYSMAL HEMOGLOBINURIA AND HOW THE TREATMENT IS - RARE DESEASES

Paroxysmal nocturnal hemoglobinuria: what it is and how the diagnosis is made



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Paroxysmal nocturnal hemoglobinuria, also known as PNH, is a rare, genetic disease characterized by a change in the red blood cell membrane, leading to its destruction and elimination of red blood cell components in the urine, thus being considered a chronic hemolytic anemia. The nocturnal term refers to the period of the day when the highest rate of destruction of red blood cells was observed in people with the disease, but investigations have shown that hemolysis, that is, the destruction of red blood cells, occurs at any time of the day in people with hemoglobinuria