ORKAMBI LEAF - AND MEDICATION

What is it for

Orkambi is a medicine used to treat cystic fibrosis in people 6 years of age or older.

Cystic fibrosis is a hereditary disease that causes the production of very thick secretions in the lungs and digestive tract, because it affects the cells that produce mucus and digestive juices, which can cause obstruction, inflammation and chronic infection. This disease may occur in childhood and adulthood. Know which symptoms are most common.

How to use

This medicinal product should only be prescribed to patients with the F508del mutation confirmed in both copies of the CFTR gene and the dose administered depends on the person's age:

Adults and children over 12 years of age: The recommended dose is 2 tablets of 200 mg of lumacaftor and 125 mg of ivacaftor, taken at 12-hour intervals with foods containing fats;

Children between 6 and 12 years of age: The recommended dose is 2 tablets of 100 mg of lumacaftor and 125 mg of ivacaftor, taken at 12-hour intervals with foods containing fats.

Foods rich in fats that can be ingested with the tablets can be meals prepared with butter or oils, foods containing eggs, cheese, nuts, whole milk or meats.

Possible side effects

The most common side effects with this medicine are shortness of breath, diarrhea, headache, dizziness, nausea, nasal congestion, expiration cough and abdominal pain.

The most serious side effects that can occur are liver problems such as elevated liver enzymes, accumulation of bile which leads to inflammation of the liver and liver encephalopathy.