Tideglusib is a drug still in the testing phase for the treatment of Alzheimer's disease and other neurological diseases such as Progressive Supranuclear Palsy. Its main action is the ability to inhibit the action of GSK-3 protein, thus preventing the phosphorylation of Tau protein and preventing the accumulation of tangles of proteins toxic to the brain, causing various brain diseases.
In addition, it has also been found that this active principle is able to regenerate the dentin and pulp of the teeth, after dental wear, and may reduce the need for procedures such as obturation.
However, because it is still in the testing phase, this drug can not be marketed until the tests are finalized and approved for use in treating people.
What is it for
Some of the possible actions of Tideglusib include the treatment of:
- Alzheimer's disease;
- Progressive supranuclear palsy;
- Repair of dental wear by reinforcing dentin;
- Autism in adolescents;
- Congenital Myotonic Muscular Dystrophy.
However, these effects are still being tested in scientific studies evaluating efficacy and safety in humans.
Main effects
The main effects of Tideglusib up to now are the reduction of various effects on the brain of Alzheimer's disease and other neurological diseases, such as Tau protein phosphorylation, amyloid protein deposition, neuronal death and brain mass, which may help memory loss. In addition, this medicine may have anti-inflammatory, neuroprotective effects that stimulate the formation of brain neurons. Check out the main treatments currently available for Alzheimer's.
Another important effect of this medicine is the ability of regeneration in the pulp of the teeth, which can help in the treatment of tooth wear by caries without the necessity of obturation. This effect was demonstrated in rats after application of biodegradable collagen sponges embedded in a compound containing Tideglusib, which stimulated the multiplication of the pulp stem cells to cover the cavities of the cavities. Also understand how caries is treated and when filling is still needed.
