Mitotane is an antineoplastic medicine known commercially as Lisodren.
This oral medication is indicated for the treatment of kidney cancer, since it has a direct effect on the adrenal gland.
Indications of the Mitotano
Kidney cancer; Cushing's syndrome.
Price of Mitotano
A 500 mg carton containing 100 tablets costs approximately 1, 200 reais.
Side Effects of Mitotane
Lethargy; somnolence; dizziness; vertigo; toxicity to the skin; lack of appetite; nausea; vomiting; diarrhea.
Contraindications of Mitotane
Pregnancy Risk C; women in the lactation phase; Hipersensibility to any of the formula's components.
How to Use Mitotane
Oral use
Adults
- Kidney cancer (inoperable): Start treatment with 1 to 6 g daily, divided into 3 or 4 doses. Increase to 9 to 10 g per day if there is good clinical response. If severe adverse reactions occur, reduce the dose to the maximum tolerated dose. The maximum daily dose indicated is 2 to 16 g. If no clinical benefit is observed after 3 months of treatment at the maximum dose indicated, it is possible that the patient will not benefit from continued treatment.
- Cushing's syndrome : Start treatment with 1 to 12 g daily in divided doses. The maintenance dose is between 500 mg (2 times per week) and 2 g per day for 3 months.
