Cosmegen is an antineoplastic antibiotic for injectable use with active ingredient actinomycin D. It works by inhibiting the multiplication of damaged cells.
Indications
Endometrial cancer; testicular cancer; rhabdomyosarcoma; botryoid sarcoma; Ewing's sarcoma; sarcoma; Wilms' tumor; trophoblastic tumor.
Side effects
Blood changes; bone marrow depression; peeling of the skin; diarrhea; abdominal pain; skin rash; lack of appetite; hyperpigmentation of the skin; inflammation in the mouth, pharynx, veins and esophagus; nausea; hair loss; severe damage to gizzard tissues; liver toxicity; redness on the skin; vomiting.
Contraindications
Pregnancy risk C; breast-feeding.
How to use
Injectable
Adults: 10 to 15 mcg / kg / day at most 5 days at 4 to 6 weeks or 500 mcg per m2 of body surface, with a maximum of 2 mg per week for 3 weeks at most.
Children: 10 to 15 mcg / kg / day or 450 mcg per m2 of body surface for a maximum of 5 days or a total dose of 2.5 mg per m2 of body surface in divided doses over a period of 7 days, a second series after 4 to 6 weeks.
