Mitostate is an antineoplastic drug that has as active substance Mitoxantrone.
This injectable drug is indicated for the treatment of leukemia as it attempts to control the disease by inhibiting the synthesis of DNA and RNA.
Indications of the Mitostate
Acute erythroid leukemia; acute myelocytic leukemia; acute monocytic leukemia; acute promyelocytic leukemia; Breast Cancer and Non-Hodgkin's Lymphomas
Mitostate price
The box of Mitostate 20 mg costs approximately between 1, 300 and 1, 400 reais.
Mitostate Side Effects
Cardiac arrhythmia; change in heart rate; Congestive heart failure; drop in blood pressure; conjunctivitis; yellowing of the skin and eyes; convulsion; Headache; fever; bone marrow depression; infection; loss of hair; diarrhea; abdominal pain; inflammation in the mouth; nausea; vomiting; difficulty breathing; chest pain; gastrointestinal bleeding; cough; ecchymosis; skin rash; necrosis of the skin; phlebitis; renal insufficiency.
Contraindications of Mitostate
Pregnancy risk D; women in the lactation phase; Hipersensibility to any of the formula's components.
How to use Mitostate
Injectable Use
Adults
- The drug should be diluted in at least 50 mL of 0.9% Sodium Chloride for injection or 5% Dextrose for injection. After this procedure the solution should be slowly introduced into the vein. The recommended starting dose is 14 mg / m 2 of body surface area in a single dose that should be repeated at 21 day intervals.
Breast Cancer and Non-Hodgkin's Lymphomas
- Administer 12 to 14 mg / m2 of body surface area intravenously, in a single dose, at intervals of 21 to 28 days.
Acute Myeloid Leukemias
- In mono-chemotherapy, administer 10 to 12 mg / m2 / day for 5 days, intravenously, lasting 10 to 15 minutes.
